“The brain is particularly vulnerable to free radical damage with its high content of unsaturated fatty acids, high oxygen metabolism (20% of total body consumption) and relatively low levels of endogenous antioxidants. Accumulation of oxidative damage in post-mitotic neurons is a crucial factor in normal brain aging, and contributes directly to cognitive, motor and sensory impairments.”

“Mitochondrial dysfunction and oxidative metabolism are principal sources of oxidative stress leading to neurodegeneration, although NAD(P)H oxidase and other sources of free radicals also contribute.

“…significantly more DNA sequence repeats in patients with schizophrenia than in control individuals, and outline a possible link between genome instability and disease.”

“Patients with clinically important CNVs showed a range of characteristics, such as developmental problems and refusal to accept treatment,” first author Itaru Kushima says. “And, the presence of two CNVs resulted in a more severe phenotype.”