Probably the Key to Self-Harming Behaviors – Broken or Insufficient μ-Opioid Receptors

the brains of morbidly obese women contained fewer μ-opioid receptors available for binding than the brains of women of normal weight. These receptors allow people to feel the intense rushes of pleasure that come with activities from eating to using heroin. “If there is insufficiency in [the food reward processing] system, the compensation would be […]

“Gambling disorder has point prevalence of around 0.5–2% across the globe, and is highly comorbid with other mental health disorders.”

Neuroimaging data suggest structural and functional abnormalities of networks involved in reward processing and top-down control. Gambling disorder shows 50–60% heritability and it is likely that various neurochemical systems are implicated in the pathophysiology (including dopaminergic, glutamatergic, serotonergic, noradrenergic, and opioidergic). Elevated rates of certain personality traits (e.g. negative urgency, disinhibition), and personality disorders, are […]