Previously, dopamine in the ventral portion of the striatum was considered to be the “pleasure” neurotransmitter involved in the action of all abused drugs. However, clinical findings suggest that drugs that block the dopamine receptor do not block methamphetamine “liking.” The dopamine story continues to evolve, with dopamine now viewed by some as a chemical involved in the motivational “wanting” aspect of drug-taking behaviour.*Salamone JD, Correa M, Farra A, et al. Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology (Berl) 2007;191:461-82.